SSRP1 antibody (AA 1-242) (Biotin)

Catalog No. ABIN7152518

Product Details anti-SSRP1 Antibody (Biotin)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Binding Specificity: AA 1-242

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSRP1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human FACT complex subunit SSRP1 protein (1-242AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Alternative Name: SSRP1 (SSRP1 Products)

Background:

Background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of \'Ser-392\' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Aliases: Chromatin-specific transcription elongation factor 80 kDa subunit antibody, Cisplatin DNA SSRP antibody, Facilitates chromatin remodeling 80 kDa subunit antibody, Facilitates chromatin transcription complex 80 kDa subunit antibody, Facilitates chromatin transcription complex subunit SSRP1 antibody, FACT 80 kDa subunit antibody, FACT complex subunit SSRP1 antibody, FACT80 antibody, FACTp80 antibody, hSSRP1 antibody, Recombination signal sequence recognition protein 1 antibody, Recombination signal sequence recognition protein antibody, SSRP 1 antibody, SSRP1 antibody, SSRP1_HUMAN antibody, Structure specific recognition protein 1 antibody, Structure-specific recognition protein 1 antibody, T160 antibody

UniProt: Q08945

Pathways: Chromatin Binding