SUPT16H antibody (AA 187-282)

Catalog No. ABIN7152513

Product Details anti-SUPT16H Antibody

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Binding Specificity: AA 187-282

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUPT16H antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human FACT complex subunit SPT16 protein (187-282AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SUPT16H

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Alternative Name: SUPT16H (SUPT16H Products)

Synonyms: CDC68 antibody, FACTP140 antibody, SPT16/CDC68 antibody, CG1828 antibody, DRE4/dSPT16 antibody, Dmel\\CG1828 antibody, SPT16 antibody, Spt16 antibody, dSPT16 antibody, dSpt16 antibody, dspt16 antibody, l(3)62Bg antibody, l(3)dre4 antibody, spt16 antibody, Cdc68 antibody, Fact140 antibody, Supt16h antibody, T12H20.3 antibody, T12H20_3 antibody, global transcription factor C antibody, SSF1 antibody, DDBDRAFT_0204912 antibody, DDBDRAFT_0231753 antibody, DDB_0204912 antibody, DDB_0231753 antibody, DUF140 antibody, SPT16 homolog, facilitates chromatin remodeling subunit antibody, FACT complex subunit spt16 antibody, FACT complex subunit SPT16 antibody, CG1828 gene product from transcript CG1828-RB antibody, suppressor of Ty 16 antibody, global transcription factor C antibody, chromatin-remodeling protein SPT16 antibody, FACT complex component Spt16 antibody, chromatin-remodeling protein antibody, global regulator of transcription antibody, FACT (FAcilitates Chromatin Transcription) complex subunit, putative antibody, SPT16 homolog, facilitates chromatin remodeling subunit S homeolog antibody, SUPT16H antibody, AOR_1_1808194 antibody, CC1G_05155 antibody, dre4 antibody, Supt16 antibody, SPT16 antibody, spt16 antibody, CDC68 antibody, Supt16h antibody, supt16h antibody, supt16h.S antibody

Background:

Background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of \'Ser-392\' of p53/TP53 via its association with CK2 (casein kinase II).

Aliases: CDC68 antibody, Chromatin specific transcription elongation factor 140 kDa subunit antibody, Chromatin-specific transcription elongation factor 140 kDa subunit antibody, Facilitates chromatin transcription complex subunit SPT16 antibody, FACT 140 kDa subunit antibody, FACT antibody, FACT complex subunit SPT16 antibody, FACTp140 antibody, FLJ10857 antibody, FLJ14010 antibody, hSPT16 antibody, SP16H_HUMAN antibody, Suppressor of Ty 16 homolog antibody, Supt16h antibody

UniProt: Q9Y5B9

Pathways: Chromatin Binding