FBXW7 antibody (AA 1-707) (HRP)

Catalog No. ABIN7152512

Product Details anti-FBXW7 Antibody (HRP)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Binding Specificity: AA 1-707

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW7 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7 (FBXW7 Products)

Synonyms: cdc4 antibody, AGO antibody, CDC4 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, SEL-10 antibody, SEL10 antibody, hAgo antibody, hCdc4 antibody, 1110001A17Rik antibody, Cdc4 antibody, Fbw7 antibody, Fbwd6 antibody, Fbx30 antibody, Fbxo30 antibody, Fbxw6 antibody, F-box and WD repeat domain containing 7 antibody, F-box and WD-40 domain protein 7 antibody, Fbxw7 antibody, FBXW7 antibody, fbxw7 antibody

Background:

Background: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).

Aliases: AGO antibody, Archipelago antibody, Archipelago homolog antibody, Archipelago, Drosophila, homolog of antibody, CDC4 antibody, CDC4, S.cerevisiae, homolog of antibody, DKFZp686F23254 antibody, F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody, F box and WD 40 domain protein 7 antibody, F box and WD repeat domain containing 7 antibody, F box protein FBW7 antibody, F box protein FBX30 antibody, F box protein SEL 10 antibody, F box protein SEL10 antibody, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody, F-box and WD-40 domain-containing protein 7 antibody, F-box protein FBX30 antibody, F-box/WD repeat-containing protein 7 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, FBXW7 antibody, FBXW7_HUMAN antibody, FLJ16457 antibody, hAgo antibody, hCdc4 antibody, Homolog of C elegans sel 10 antibody, Homolog of C.elegans sel10 antibody, SEL 10 antibody, SEL-10 antibody, SEL10 antibody

UniProt: Q969H0

Pathways: Notch Signaling, EGFR Signaling Pathway