FBXO9 antibody (AA 13-111)

Catalog No. ABIN7152451

Product Details anti-FBXO9 Antibody

Target: FBXO9 (F-Box Protein 9 (FBXO9))

Binding Specificity: AA 13-111

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO9 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human F-box only protein 9 protein (13-111AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FBXO9

Target: FBXO9 (F-Box Protein 9 (FBXO9))

Alternative Name: FBXO9 (FBXO9 Products)

Synonyms: fbxo9 antibody, MGC75727 antibody, FBXO9 antibody, fbx9 antibody, FBX9 antibody, NY-REN-57 antibody, VCIA1 antibody, dJ341E18.2 antibody, wu:fc79g12 antibody, zgc:56212 antibody, zgc:77654 antibody, 9030401P18Rik antibody, AA986398 antibody, F-box protein 9 antibody, F-box only protein 9 antibody, f-box protein 9 antibody, F-box protein 9 L homeolog antibody, fbxo9 antibody, FBXO9 antibody, CpipJ_CPIJ012920 antibody, Tsp_03945 antibody, fbx9 antibody, Fbxo9 antibody, fbxo9.L antibody

Background:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Aliases: Cross-immune reaction antigen 1 antibody, dJ341E18.2 antibody, DKFZp434C0118 antibody, F-box only protein 9 antibody, Fbp24 antibody, FBX09 antibody, FBX9 antibody, FBX9_HUMAN antibody, Fbxo9 antibody, KIAA0936 antibody, NY REN 57 antibody, OTTHUMP00000016628 antibody, OTTHUMP00000016629 antibody, OTTHUMP00000214588 antibody, Renal carcinoma antigen NY-REN-57 antibody, VCIA1 antibody

UniProt: Q9UK97