FBXO6 antibody (AA 104-293)

Catalog No. ABIN7152447

Product Details anti-FBXO6 Antibody

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Binding Specificity: AA 104-293

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human F-box only protein 6 protein (104-293AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FBXO6

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Alternative Name: FBXO6 (FBXO6 Products)

Synonyms: FBG2 antibody, FBS2 antibody, FBX6 antibody, Fbx6b antibody, AA408845 antibody, Fbs2 antibody, Fbxo6b antibody, Fbg2 antibody, FBXO6 antibody, fbg2 antibody, fbs2 antibody, fbx6 antibody, fbx6b antibody, fbxo44 antibody, F-box protein 6 antibody, F-box protein 6 S homeolog antibody, FBXO6 antibody, Fbxo6 antibody, fbxo6.S antibody

Background:

Background: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on \\\'Ser-345\\\'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Aliases: F box protein that recognizes sugar chains 2 antibody, F box G domain protein 2 antibody, F box only protein 6 antibody, F box protein 6 antibody, F box protein FBG2 antibody, F box protein Fbx6 antibody, F box/G domain protein 2 antibody, F-box only protein 6 antibody, F-box protein that recognizes sugar chains 2 antibody, F-box/G-domain protein 2 antibody, FBG 2 antibody, FBG2 antibody, FBS 2 antibody, FBS2 antibody, FBX 6 antibody, FBX6 antibody, FBX6_HUMAN antibody, FBXO 6 antibody, FBXO6 antibody, OTTHUMP00000002267 antibody

UniProt: Q9NRD1