FBXO2 antibody (AA 1-296)

Catalog No. ABIN7152410

Product Details anti-FBXO2 Antibody

Target: FBXO2 (F-Box Protein 2 (FBXO2))

Binding Specificity: AA 1-296

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human F-box only protein 2 protein (1-296AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FBXO2

Target: FBXO2 (F-Box Protein 2 (FBXO2))

Alternative Name: FBXO2 (FBXO2 Products)

Synonyms: FBG1 antibody, FBX2 antibody, Fbs1 antibody, NFB42 antibody, OCP1 antibody, Fbs2 antibody, Prpl4 antibody, F-box protein 2 antibody, FBXO2 antibody, Fbxo2 antibody

Background:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).

Aliases: F box gene 1 antibody, F box only protein 2 antibody, F box protein 2 antibody, F box protein only 2 antibody, F-box only protein 2 antibody, FBG 1 antibody, FBG1 antibody, Fbs 1 antibody, Fbs1 antibody, Fbs2 antibody, FBX 2 antibody, FBX2 antibody, FBX2_HUMAN antibody, FBXO 2 antibody, FBXO2 antibody, Neural F box protein NFB42 antibody, Neural F-box protein, 42-KD, rat, homolog of antibody, NFB 42 antibody, NFB42 antibody, OCP1 antibody, organ of Corti protein 1 antibody, Prpl4 antibody

UniProt: Q9UK22