EYA2 antibody (AA 1-514)

Catalog No. ABIN7152359

Product Details anti-EYA2 Antibody

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Binding Specificity: AA 1-514

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Eyes absent homolog 2 protein (1-514AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EYA2

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Alternative Name: EYA2 (EYA2 Products)

Synonyms: EYA2 antibody, zgc:92279 antibody, eab1 antibody, Eab1 antibody, EAB1 antibody, EYA transcriptional coactivator and phosphatase 2 antibody, EYA2 antibody, eya2 antibody, Eya2 antibody

Background:

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates \'Tyr-142\' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. \'Tyr-142\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1.

Aliases: EAB 1 antibody, EAB1 antibody, EYA 2 antibody, EYA transcriptional coactivator and phosphatase 2 antibody, EYA2 antibody, EYA2_HUMAN antibody, eyes absent 2 homolog (Drosophila) antibody, Eyes absent homolog 2 (Drosophila) antibody, Eyes absent homolog 2 antibody, Translation of this uORF probably lowers the translation efficiency of EYA2 antibody

UniProt: O00167