EYA1 antibody (AA 168-321)

Catalog No. ABIN7152355

Product Details anti-EYA1 Antibody

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Binding Specificity: AA 168-321

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Eyes absent homolog 1 protein (168-321AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EYA1

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Alternative Name: EYA1 (EYA1 Products)

Synonyms: EYA1 antibody, bop antibody, bor antibody, XEya1 antibody, wu:fc13c10 antibody, zgc:100770 antibody, BOP antibody, BOR antibody, BOS1 antibody, EYA transcriptional coactivator and phosphatase 1 antibody, EYA transcriptional coactivator and phosphatase 1 L homeolog antibody, EYA1 antibody, eya1 antibody, Eya1 antibody, eya1.L antibody

Background:

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2 (By similarity).

Aliases: BOP antibody, BOR antibody, BOS1 antibody, EYA transcriptional coactivator and phosphatase 1 antibody, Eya1 antibody, EYA1_HUMAN antibody, Eyes absent 1 antibody, Eyes absent 1 homolog antibody, Eyes absent homolog 1 (Drosophila) antibody, Eyes absent homolog 1 antibody, Eyes absent homolog1 antibody, MGC141875 antibody, OFC1 antibody

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus