EXOSC1 antibody (AA 587-762) (HRP)

Catalog No. ABIN7152304

Product Details anti-EXOSC1 Antibody (HRP)

Target: EXOSC1 (Exosome Component 1 (EXOSC1))

Binding Specificity: AA 587-762

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Exosome component 10 protein (587-762AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EXOSC1

Target: EXOSC1 (Exosome Component 1 (EXOSC1))

Alternative Name: EXOSC1 (EXOSC1 Products)

Synonyms: MGC86284 antibody, CGI-108 antibody, CSL4 antibody, Csl4p antibody, SKI4 antibody, Ski4p antibody, hCsl4p antibody, p13 antibody, 2610035C18Rik antibody, 2610104C07Rik antibody, 2610312F07Rik antibody, AI447561 antibody, exosome component 1 antibody, exosome component 1 L homeolog antibody, EXOSC1 antibody, exosc1.L antibody, exosc1 antibody, PTRG_05845 antibody, Exosc1 antibody

Background:

Background: Putative catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3\'-5\' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Aliases: Autoantigen PM/Scl 2 antibody, Exosc10 antibody, Exosome component 10 antibody, EXOSX_HUMAN antibody, P100 polymyositis scleroderma overlap syndrome associated autoantigen antibody, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody, p2 antibody, p3 antibody, p4 antibody, PM Scl antibody, PM/Scl 100 antibody, PM/Scl-100 antibody, PMSCL antibody, PMSCL2 antibody, Polymyositis/scleroderma autoantigen 100 kDa antibody, Polymyositis/scleroderma autoantigen 2 100 kDa antibody, Polymyositis/scleroderma autoantigen 2 antibody, RRP6 antibody, Rrp6p antibody

UniProt: Q01780