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DIS3 antibody (AA 30-187)

DIS3 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7152297
  • Target See all DIS3 Antibodies
    DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
    Binding Specificity
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 30-187
    Reactivity
    • 44
    • 16
    • 8
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 39
    • 5
    Rabbit
    Clonality
    • 42
    • 2
    Polyclonal
    Conjugate
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIS3 antibody is un-conjugated
    Application
    • 34
    • 21
    • 14
    • 7
    • 6
    • 4
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Exosome complex exonuclease RRP44 protein (30-187AA)
    Isotype
    IgG
    Top Product
    Discover our top product DIS3 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
    Alternative Name
    DIS3 (DIS3 Products)
    Synonyms
    EXOSC11 antibody, KIAA1008 antibody, RP11-342J4.3 antibody, RRP44 antibody, bA555G22.1 antibody, dis3p antibody, DIS3 antibody, 2810028N01Rik antibody, RGD1304646 antibody, wu:fb08g12 antibody, dis3 antibody, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 antibody, Dis3 antibody, dis3 antibody, dis3.L antibody
    Background

    Background: Putative catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3\'-5\' exonuclease and endonuclease activities.

    Aliases: 2810028N01Rik antibody, bA555G22 antibody, Dis3 antibody, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 mitotic control homolog (S. cerevisiae) antibody, DIS3 mitotic control homolog antibody, DIS3 mitotic control, S. cerevisiae, homolog of antibody, dis3p antibody, EXOSC11 antibody, Exosome complex exonuclease RRP44 antibody, exosome component 11 antibody, KIAA1008 antibody, Mitotic control protein dis3 homolog antibody, Protein DIS3 homolog antibody, Ribosomal RNA processing protein 44 antibody, Ribosomal RNA processing protein 44, S. cerevisiae, homolog of antibody, Ribosomal RNA-processing protein 44 antibody, RP11-342J4.3 antibody, RRP44 antibody, RRP44_HUMAN antibody

    UniProt
    Q9Y2L1
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