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EXOSC8 antibody (AA 2-276) (FITC)

EXOSC8 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7152291
  • Target See all EXOSC8 Antibodies
    EXOSC8 (Exosome Component 8 (EXOSC8))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    AA 2-276
    Reactivity
    • 17
    • 2
    • 1
    Human
    Host
    • 14
    • 3
    Rabbit
    Clonality
    • 14
    • 3
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    This EXOSC8 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Exosome complex component RRP43 protein (2-276AA)
    Isotype
    IgG
    Top Product
    Discover our top product EXOSC8 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    EXOSC8 (Exosome Component 8 (EXOSC8))
    Alternative Name
    EXOSC8 (EXOSC8 Products)
    Synonyms
    wu:fb79a10 antibody, zgc:110381 antibody, MGC52847 antibody, MGC132146 antibody, EXOSC8 antibody, MGC79733 antibody, CIP3 antibody, EAP2 antibody, OIP2 antibody, RP11-421P11.3 antibody, RRP43 antibody, Rrp43p antibody, bA421P11.3 antibody, p9 antibody, 2310032N20Rik antibody, mKIAA4013 antibody, exosome component 8 antibody, exosome component 8 S homeolog antibody, Exosc8 antibody, exosc8 antibody, exosc8.S antibody, EXOSC8 antibody
    Background

    Background: Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.

    Aliases: bA421P11.3 antibody, CBP interacting protein 3 antibody, CIP3 antibody, EAP2 antibody, EC 3.1.13 antibody, EXOS8_HUMAN antibody, EXOSC8 antibody, Exosome complex component RRP43 antibody, Exosome complex exonuclease RRP43 antibody, Exosome component 8 antibody, OIP-2 antibody, OIP2 antibody, Opa interacting protein 2 antibody, Opa-interacting protein 2 antibody, OTTHUMP00000042274 antibody, p9 antibody, Ribosomal RNA processing protein 43 antibody, Ribosomal RNA processing protein 43, S. cerevisiae, homolog of antibody, Ribosomal RNA-processing protein 43 antibody, RP11 421P11.3 antibody, RRP43 antibody, Rrp43p antibody

    UniProt
    Q96B26
    Pathways
    SARS-CoV-2 Protein Interactome
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