EIF6 antibody (AA 1-245)

Catalog No. ABIN7152221

Product Details anti-EIF6 Antibody

Target: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Binding Specificity: AA 1-245

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF6 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Eukaryotic translation initiation factor 6 protein (1-245AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EIF6

Target: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Alternative Name: EIF6 (EIF6 Products)

Synonyms: CAB antibody, EIF3A antibody, ITGB4BP antibody, b(2)gcn antibody, eIF-6 antibody, p27(BBP) antibody, p27BBP antibody, 1110004P11 antibody, AA408895 antibody, Itgb4bp antibody, imc-415 antibody, MGC56562 antibody, itgb4bp4 antibody, zgc:56562 antibody, wu:fc28a04 antibody, wu:ft88f05 antibody, itgb4bp antibody, eukaryotic translation initiation factor 6 antibody, Eukaryotic translation initiation factor 6 antibody, eukaryotic translation initiation factor 6 S homeolog antibody, translation initiation factor eIF6 antibody, EIF6 antibody, Eif6 antibody, eif6 antibody, eif-6 antibody, eif6.S antibody, tif6 antibody

Background:

Background: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.

Aliases: b(2)gcn antibody, B(2)GCN homolog antibody, B4 integrin interactor antibody, Binding protein of beta-4 integrin antibody, CAB antibody, eIF-6 antibody, EIF3A antibody, EIF6 antibody, Eukaryotic translation initiation factor 3A antibody, Eukaryotic translation initiation factor 6 antibody, IF6_HUMAN antibody, Integrin beta 4 binding protein antibody, ITGB4BP antibody, OK/SW-cl.27 antibody, p27 beta 4 integrin binding protein antibody, p27(BBP) antibody, p27BBP antibody, RP4-614O4.1 antibody

UniProt: P56537

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly