EIF3S1 antibody (AA 5-115)

Catalog No. ABIN7152166

Product Details anti-EIF3S1 Antibody

Target: EIF3S1 (Eukaryotic Translation Initiation Factor 3 Subunit J (EIF3S1))

Binding Specificity: AA 5-115

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3S1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Eukaryotic translation initiation factor 3 subunit J protein (5-115AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EIF3S1

Target: EIF3S1 (Eukaryotic Translation Initiation Factor 3 Subunit J (EIF3S1))

Alternative Name: EIF3J (EIF3S1 Products)

Background:

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.

Aliases: eIF 3 alpha antibody, eIF-3-alpha antibody, eIF3 alpha antibody, eIF3 p35 antibody, eIF3j antibody, EIF3J_HUMAN antibody, EIF3S 1 antibody, EIF3S1 antibody, Eukaryotic translation initiation factor 3 subunit 1 antibody, Eukaryotic translation initiation factor 3 subunit J antibody, Eukaryotic translation initiation factor 3, subunit 1 (alpha, 35kD) antibody, Eukaryotic translation initiation factor 3, subunit 1 alpha, 35kD antibody

UniProt: O75822

Pathways: Ribonucleoprotein Complex Subunit Organization