ERLIN2 antibody (AA 25-206)

Catalog No. ABIN7151998

Product Details anti-ERLIN2 Antibody

Target: ERLIN2 (ER Lipid Raft Associated 2 (ERLIN2))

Binding Specificity: AA 25-206

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERLIN2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Erlin-2 protein (25-206AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ERLIN2

Target: ERLIN2 (ER Lipid Raft Associated 2 (ERLIN2))

Alternative Name: ERLIN2 (ERLIN2 Products)

Synonyms: C8orf2 antibody, Erlin-2 antibody, NET32 antibody, SPFH2 antibody, SPG18 antibody, BC036333 antibody, C87251 antibody, Spfh2 antibody, Erlin-2-B antibody, erlin1 antibody, spfh1 antibody, spfh2 antibody, spfh2-B antibody, RGD1309010 antibody, SPFH domain-containing protein 2-A antibody, erlin2 antibody, erlin2-a antibody, erlin2-b antibody, spfh2-A antibody, ER lipid raft associated 2 antibody, erlin-2 antibody, Erlin-2 antibody, ER lipid raft associated 2 S homeolog antibody, ER lipid raft associated 2 L homeolog antibody, ERLIN2 antibody, erlin2 antibody, Tsp_03442 antibody, erln2 antibody, Erlin2 antibody, erlin2.S antibody, erlin2.L antibody

Background:

Background: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618).

Aliases: C8orf2 antibody, Chromosome 8 open reading frame 2 antibody, Endoplasmic reticulum lipid raft associated protein 2 antibody, Endoplasmic reticulum lipid raft-associated protein 2 antibody, ER lipid raft associated 2 antibody, ERLIN 2 antibody, Erlin-2 antibody, ERLIN2 antibody, ERLN2_HUMAN antibody, HGNC:1356 antibody, MGC87072 antibody, NET32 antibody, SPFH 2 antibody, SPFH domain containing protein 2 antibody, SPFH domain family member 2 antibody, SPFH domain-containing protein 2 antibody, SPFH2 antibody, SPG18 antibody, Stomatin prohibitin flotillin HflC/K domain containing protein 2 antibody, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 antibody

UniProt: O94905