EDEM2 antibody (AA 22-300)

Catalog No. ABIN7151974

Product Details anti-EDEM2 Antibody

Target: EDEM2 (ER Degradation Enhancer, Mannosidase alpha-Like 2 (EDEM2))

Binding Specificity: AA 22-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDEM2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EDEM2

Target: EDEM2 (ER Degradation Enhancer, Mannosidase alpha-Like 2 (EDEM2))

Alternative Name: EDEM2 (EDEM2 Products)

Synonyms: C20orf31 antibody, C20orf49 antibody, bA4204.1 antibody, 9530090G24Rik antibody, AI327354 antibody, RGD1303074 antibody, MGC88910 antibody, DKFZp459A0314 antibody, ER degradation enhancing alpha-mannosidase like protein 2 antibody, ER degradation enhancer, mannosidase alpha-like 2 antibody, EDEM2 antibody, Edem2 antibody, edem2 antibody

Background:

Background: Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.

Aliases: bA4204.1 antibody, C20orf31 antibody, C20orf49 antibody, EDEM 2 antibody, EDEM2 antibody, EDEM2_HUMAN antibody, ER degradation enhancer mannosidase alpha like 2 antibody, ER degradation enhancing alpha mannosidase like 2 antibody, ER degradation enhancing alpha mannosidase like protein 2 antibody, ER degradation enhancing mannosidase like protein 2 antibody, ER degradation-enhancing alpha-mannosidase-like 2 antibody, FLJ10783 antibody, UNQ573/PRO1135 antibody

UniProt: Q9BV94