EMP2 antibody (AA 22-66) (Biotin)

Catalog No. ABIN7151930

Product Details anti-EMP2 Antibody (Biotin)

Target: EMP2 (Epithelial Membrane Protein 2 (EMP2))

Binding Specificity: AA 22-66

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EMP2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Epithelial membrane protein 2 protein (22-66AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EMP2

Target: EMP2 (Epithelial Membrane Protein 2 (EMP2))

Alternative Name: EMP2 (EMP2 Products)

Synonyms: MGC52916 antibody, MGC130799 antibody, MGC69514 antibody, emp2 antibody, XMP antibody, epithelial membrane protein 2 L homeolog antibody, epithelial membrane protein 2 antibody, emp2.L antibody, emp2 antibody, EMP2 antibody, Emp2 antibody

Background:

Background: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).

Aliases: EMP 2 antibody, EMP-2 antibody, EMP2 antibody, EMP2_HUMAN antibody, Epithelial membrane protein 2 antibody, Protein XMP antibody

UniProt: P54851