Ephrin A1 antibody (AA 19-182)

Catalog No. ABIN7151874

Product Details anti-Ephrin A1 Antibody

Target: Ephrin A1 (EFNA1)

Binding Specificity: AA 19-182

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ephrin A1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ephrin-A1 protein (19-182AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Ephrin A1

Target: Ephrin A1 (EFNA1)

Alternative Name: EFNA1 (EFNA1 Products)

Synonyms: Xefrin-A1 antibody, b61 antibody, ecklg antibody, efl1 antibody, efna1 antibody, efna1a antibody, elfa-a antibody, epha1 antibody, eplg1 antibody, lerk1 antibody, tnfaip4 antibody, xelf-a' antibody, xelfa antibody, AI325262 antibody, B61 antibody, Efl1 antibody, Epl1 antibody, Eplg1 antibody, Lerk1 antibody, ECKLG antibody, EFL1 antibody, EPLG1 antibody, LERK-1 antibody, LERK1 antibody, TNFAIP4 antibody, efna1b antibody, MGC130661 antibody, ephrin-A1 S homeolog antibody, ephrin-A1 antibody, ephrin A1 antibody, ephrin-A1b antibody, ephrin-A1 L homeolog antibody, efna1.S antibody, efna1 antibody, EFNA1 antibody, efna1b antibody, Efna1 antibody, efna1.L antibody

Background:

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Aliases: B61 antibody, ECKLG antibody, EFL 1 antibody, EFL1 antibody, EFNA 1 antibody, Efna1 antibody, EFNA1_HUMAN antibody, EPH related receptor tyrosine kinase ligand 1 antibody, EPH-related receptor tyrosine kinase ligand 1 antibody, Ephrin-A1 antibody, Ephrin-A1, secreted form antibody, EphrinA1 antibody, EPLG 1 antibody, EPLG1 antibody, Immediate early response protein B61 antibody, LERK 1 antibody, LERK-1 antibody, LERK1 antibody, Ligand of eph related kinase 1 antibody, OTTHUMP00000033242 antibody, OTTHUMP00000033271 antibody, secreted form antibody, TNF alpha-induced protein 4 antibody, TNFAIP 4 antibody, TNFAIP4 antibody, Tumor necrosis factor alpha induced protein 4 antibody, Tumor necrosis factor alpha-induced protein 4 antibody

UniProt: P20827

Pathways: RTK Signaling