EPH Receptor A4 antibody (AA 345-545)

Catalog No. ABIN7151839

Product Details anti-EPH Receptor A4 Antibody

Target: EPH Receptor A4 (EPHA4)

Binding Specificity: AA 345-545

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor A4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ephrin type-A receptor 4 protein (345-545AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EPH Receptor A4

Target: EPH Receptor A4 (EPHA4)

Alternative Name: EPHA4 (EPHA4 Products)

Synonyms: HEK8 antibody, SEK antibody, TYRO1 antibody, RGD1560587 antibody, ephe antibody, EPHA4 antibody, Ci-Eph1 antibody, sek antibody, hek8 antibody, rtk1 antibody, tyr01 antibody, 2900005C20Rik antibody, AI385584 antibody, Cek8 antibody, Hek8 antibody, Sek antibody, Sek1 antibody, Tyro1 antibody, rb antibody, XEpha4 antibody, sek-1 antibody, epha4 antibody, pag antibody, EphA4 antibody, apha3 antibody, ek2 antibody, epha3 antibody, sb:cb246 antibody, zek2 antibody, zgc:109882 antibody, EPH receptor A4 antibody, Eph receptor A4 antibody, ephrin receptor epsilon antibody, EPH receptor A4 S homeolog antibody, EPH receptor A4 L homeolog antibody, eph receptor A4a antibody, EPHA4 antibody, Epha4 antibody, ephe antibody, epha4 antibody, epha4.S antibody, epha4.L antibody, epha4a antibody

Background:

Background: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at \'Tyr-15\' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Aliases: Cek 8 antibody, CEK8 antibody, EK8 antibody, eph receptor a4 antibody, EPH-like kinase 8 antibody, EPHA4 antibody, EPHA4_HUMAN antibody, Ephrin type-A receptor 4 antibody, HEK 8 antibody, hEK8 antibody, Receptor protein-tyrosine kinase HEK8 antibody, Sek 1 antibody, SEK antibody, TYRO 1 protein tyrosine kinase antibody, TYRO1 antibody, Tyrosine-protein kinase receptor SEK antibody, Tyrosine-protein kinase TYRO1 antibody

UniProt: P54764

Pathways: RTK Signaling