NGEF antibody (AA 495-710) (FITC)
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- Target See all NGEF Antibodies
- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
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Binding Specificity
- AA 495-710
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NGEF antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Ephexin-1 protein (495-710AA)
- Isotype
- IgG
- Top Product
- Discover our top product NGEF Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
- Alternative Name
- NGEF (NGEF Products)
- Synonyms
- Ephexin-1 antibody, ARHGEF27 antibody, EPHEXIN antibody, Tims2 antibody, ephexin antibody, Besh3 antibody, ephexin-1 antibody, neuronal guanine nucleotide exchange factor antibody, NGEF antibody, Ngef antibody
- Background
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Background: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Aliases: ARHGEF27 antibody, Eph receptor-interacting exchange protein antibody, Eph-interacting exchange protein antibody, EPHEXIN antibody, Ephexin-1 antibody, Guanine nucleotide exchange factor, neuronal antibody, Neuronal guanine nucleotide exchange factor antibody, Ngef antibody, NGEF_HUMAN antibody
- UniProt
- Q8N5V2
- Pathways
- Neurotrophin Signaling Pathway
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