Nth Endonuclease III-Like 1 (NTHL1) (AA 31-312) antibody (HRP)

Catalog No. ABIN7151638

Product Details

Target: Nth Endonuclease III-Like 1 (NTHL1)

Binding Specificity: AA 31-312

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Endonuclease III-like protein 1 protein (31-312AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Nth Endonuclease III-Like 1 (NTHL1)

Alternative Name: NTHL1 (NTHL1 Products)

Synonyms: psmc3 antibody, psmc3-a antibody, nth-like DNA glycosylase 1 S homeolog antibody, nthl1.S antibody

Background:

Background: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3\' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Aliases: Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase antibody, DNA glycoslyase/AP lyase antibody, Endonuclease III like protein 1 antibody, Endonuclease III-like protein 1 antibody, hNTH1 antibody, NTH 1 antibody, nth endonuclease III like 1 (E. coli) antibody, NTH endonuclease III Like 1 antibody, NTH1 antibody, NTHL 1 antibody, Nthl1 antibody, NTHL1_HUMAN antibody, OCTS 3 antibody, OCTS3 antibody

UniProt: P78549