NEIL1 antibody (AA 2-390) (Biotin)

Catalog No. ABIN7151628

Product Details anti-NEIL1 Antibody (Biotin)

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Binding Specificity: AA 2-390

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEIL1 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Endonuclease 8-like 1 protein (2-390AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NEIL1

Target: NEIL1 (Endonuclease VIII-Like 1 (NEIL1))

Alternative Name: NEIL1 (NEIL1 Products)

Synonyms: FPG1 antibody, NEI1 antibody, hFPG1 antibody, 2810450N13Rik antibody, Nei1 antibody, nei-like DNA glycosylase 1 antibody, nei like DNA glycosylase 1 antibody, nei endonuclease VIII-like 1 (E. coli) antibody, Neil1 antibody, NEIL1 antibody

Background:

Background: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3\'- and 5\'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Aliases: DNA (apurinic or apyrimidinic site) lyase Neil1 antibody, DNA glycosylase/AP lyase Neil 1 antibody, DNA glycosylase/AP lyase Neil1 antibody, DNA-(apurinic or apyrimidinic site) lyase Neil1 antibody, Endonuclease 8 like 1 antibody, Endonuclease 8-like 1 antibody, Endonuclease VIII antibody, Endonuclease VIII like 1 antibody, Endonuclease VIII-like 1 antibody, FLJ22402 antibody, FPG1 antibody, hFPG1 antibody, NEH 1 antibody, NEH1 antibody, NEI 1 antibody, Nei endonuclease VIII like 1 (E. coli) antibody, Nei endonuclease VIII like 1 antibody, Nei homolog 1 antibody, Nei like 1 antibody, Nei like protein 1 antibody, Nei-like protein 1 antibody, NEI1 antibody, NEIL 1 antibody, Neil1 antibody, NEIL1_HUMAN antibody

UniProt: Q96FI4

Pathways: DNA Damage Repair