TRIM33 antibody (AA 1-273) (HRP)

Catalog No. ABIN7151261

Product Details anti-TRIM33 Antibody (HRP)

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Binding Specificity: AA 1-273

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM33 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRIM33

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Alternative Name: TRIM33 (TRIM33 Products)

Synonyms: TRIM33 antibody, ptc7 antibody, rfg7 antibody, tf1g antibody, tif1g antibody, tifgamma antibody, MGC146665 antibody, tif1gamma antibody, ECTO antibody, PTC7 antibody, RFG7 antibody, TF1G antibody, TIF1G antibody, TIF1GAMMA antibody, TIFGAMMA antibody, ecto antibody, 8030451N04Rik antibody, AI413936 antibody, Ecto antibody, Tif1g antibody, ectodermin antibody, mKIAA1113 antibody, cb1085 antibody, id:ibd2175 antibody, mon antibody, wu:fc17f10 antibody, zgc:136680 antibody, tripartite motif containing 33 antibody, tripartite motif containing 33 L homeolog antibody, tripartite motif-containing 33 antibody, TRIM33 antibody, trim33 antibody, trim33.L antibody, Trim33 antibody

Background:

Background: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Aliases: 8030451N04Rik antibody, AI413936 antibody, cb1085 antibody, DKFZp586K1123 antibody, E3 ubiquitin-protein ligase TRIM33 antibody, EC 6.3.2.- antibody, Ectodermin antibody, Ectodermin homolog antibody, FLJ11429 antibody, FLJ32925 antibody, id:ibd2175 antibody, MGC136680 antibody, mKIAA1113 antibody, OTTHUMP00000013662 antibody, OTTHUMP00000013663 antibody, Protein Rfg7 antibody, PTC7 antibody, Ret fused gene 7 antibody, RET-fused gene 7 protein antibody, RFG7 antibody, Rfg7 protein antibody, TF1G antibody, TIF1 gamma antibody, TIF1-gamma antibody, TIF1G antibody, TIF1GAMMA antibody, TIFGAMMA antibody, Transcription intermediary factor 1-gamma antibody, Transcriptional intermediary factor 1 gamma antibody, TRI33_HUMAN antibody, trim33 antibody, Tripartite motif containing 33 antibody, Tripartite motif containing 33 protein antibody, tripartite motif-containing 33 antibody, Tripartite motif-containing protein 33 antibody, wu:fc17f10 antibody, zgc:136680 antibody

UniProt: Q9UPN9