TRIM13 antibody (AA 40-310)

Catalog No. ABIN7151243

Product Details anti-TRIM13 Antibody

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Binding Specificity: AA 40-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase TRIM13 protein (40-310AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRIM13

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Alternative Name: TRIM13 (TRIM13 Products)

Synonyms: TRIM13 antibody, RFP2 antibody, CAR antibody, DLEU5 antibody, LEU5 antibody, RNF77 antibody, 3110001L12Rik antibody, Rfp2 antibody, tripartite motif containing 13 antibody, ret finger protein 2 antibody, tripartite motif-containing 13 antibody, TRIM13 antibody, LOC100338599 antibody, Trim13 antibody

Background:

Background: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Aliases: B cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody, B-cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody, CAR antibody, DLEU5 antibody, E3 ubiquitin-protein ligase TRIM13 antibody, HGNC:9976 antibody, LEU5 antibody, Leukemia associated protein 5 antibody, Leukemia-associated protein 5 antibody, Putative tumor suppressor RFP2 antibody, Ret finger protein 2 antibody, RFP2 antibody, RING finger protein 77 antibody, RNF77 antibody, TRI13_HUMAN antibody, Trim13 antibody, Tripartite motif protein 13 antibody, Tripartite motif-containing protein 13 antibody

UniProt: O60858