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SIAH2 antibody (AA 1-72) (FITC)

SIAH2 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7151220
  • Target See all SIAH2 Antibodies
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-72
    Reactivity
    • 36
    • 16
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 34
    • 2
    Polyclonal
    Conjugate
    • 17
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIAH2 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human E3 ubiquitin-protein ligase SIAH2 protein (1-72AA)
    Isotype
    IgG
    Top Product
    Discover our top product SIAH2 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    Alternative Name
    SIAH2 (SIAH2 Products)
    Synonyms
    hSiah2 antibody, Xsiah-2 antibody, siah2-A antibody, xsiah2 antibody, AA415433 antibody, Sinh2 antibody, siah E3 ubiquitin protein ligase 2 antibody, siah E3 ubiquitin protein ligase 2 L homeolog antibody, seven in absentia 2 antibody, SIAH2 antibody, siah2.L antibody, Siah2 antibody
    Background

    Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

    Aliases: E3 ubiquitin-protein ligase Siah2 antibody, hSiah2 antibody, Seven in absentia homolog 2 antibody, Siah E3 ubiquitin protein ligase 2 antibody, Siah-2 antibody, siah2 antibody, SIAH2_HUMAN antibody, Ubiquitin Ligase Siah2 antibody

    UniProt
    O43255
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