RNF4 antibody (AA 1-103)

Catalog No. ABIN7151194

Product Details anti-RNF4 Antibody

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Binding Specificity: AA 1-103

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF4

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Alternative Name: RNF4 (RNF4 Products)

Synonyms: SLX5 antibody, SNURF antibody, AU018689 antibody, Gtrgeo8 antibody, ring finger protein 4 antibody, RNF4 antibody, Rnf4 antibody

Background:

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Aliases: E3 ubiquitin ligase RNF4 antibody, E3 ubiquitin protein ligase RNF4 antibody, Protein SNURF antibody, RES4 26 antibody, RING finger protein 4 antibody, Rnf4 antibody, RNF4_HUMAN antibody, SLX5 antibody, Small nuclear ring finger protein antibody, SNURF antibody

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway