RNF34 antibody (AA 1-220)

Catalog No. ABIN7151192

Product Details anti-RNF34 Antibody

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Binding Specificity: AA 1-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF34 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF34 protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Alternative Name: RNF34 (RNF34 Products)

Synonyms: CARP-1 antibody, CARP1 antibody, RFI antibody, RIF antibody, RIFF antibody, hRFI antibody, rnf34 antibody, AW061037 antibody, AW536122 antibody, BC004042 antibody, C88279 antibody, Momo antibody, fi35g06 antibody, wu:fi35g06 antibody, zgc:114043 antibody, zgc:171755 antibody, ring finger protein 34 antibody, E3 ubiquitin-protein ligase RNF34 antibody, ring finger protein 34a antibody, ring finger protein 34b antibody, Residual feed intake antibody, RNF34 antibody, rnf34 antibody, Rnf34 antibody, rnf34a antibody, rnf34b antibody, RFI antibody

Background:

Background: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate \\\'Lys-48\\\'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through \\\'Lys-48\\\'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Aliases: CARP 1 antibody, CARP-1 antibody, CARP1 antibody, Caspase regulator CARP1 antibody, Caspases-8 and -10-associated RING finger protein 1 antibody, E3 ubiquitin-protein ligase RNF34 antibody, FYVE-RING finger protein Momo antibody, hRFI antibody, Human RING finger homologous to inhibitor of apoptosis protein antibody, RFI antibody, RIF antibody, RIFF antibody, RING finger protein 34 antibody, RING finger protein RIFF antibody, RNF34 antibody, RNF34_HUMAN antibody

UniProt: Q969K3