RNF41 antibody (AA 1-317)

Catalog No. ABIN7151092

Product Details anti-RNF41 Antibody

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Binding Specificity: AA 1-317

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF41 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF41

Target: RNF41 (Ring Finger Protein 41 (RNF41))

Alternative Name: RNF41 (RNF41 Products)

Synonyms: FLRF antibody, NRDP1 antibody, 2210404G21Rik antibody, 4930511A05Rik antibody, 4933415P08Rik antibody, D10Ertd722e antibody, Nrdp1 antibody, wu:fi13f07 antibody, wu:fi25b06 antibody, zgc:55389 antibody, flrf antibody, ring finger protein 41 antibody, ring finger protein 41 S homeolog antibody, ring finger protein 41, E3 ubiquitin protein ligase antibody, RNF41 antibody, Rnf41 antibody, rnf41 antibody, rnf41.S antibody

Background:

Background: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Aliases: 4930511A05Rik antibody, 4933415P08Rik antibody, E3 ubiquitin protein ligase NRDP1 antibody, E3 ubiquitin-protein ligase NRDP1 antibody, Fetal Liver RING finger protein antibody, FLRF antibody, MGC45228 antibody, Neuregulin receptor degradation protein 1 antibody, NRDP1 antibody, RING finger protein 41 antibody, rnf41 antibody, RNF41_HUMAN antibody, SBBI03 antibody

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interactome