STUB1 antibody (AA 1-48)

Catalog No. ABIN7151009

Product Details anti-STUB1 Antibody

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Binding Specificity: AA 1-48

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STUB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase CHIP protein (1-48AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for STUB1

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Alternative Name: STUB1 (STUB1 Products)

Synonyms: CHIP antibody, HSPABP2 antibody, NY-CO-7 antibody, SDCCAG7 antibody, UBOX1 antibody, 0610033N24Rik antibody, 2210017D18Rik antibody, 2310040B03Rik antibody, AW046544 antibody, Chip antibody, wu:fc22f04 antibody, zgc:56076 antibody, STUB1 antibody, chip antibody, ATCHIP antibody, CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN antibody, carboxyl terminus of HSC70-interacting protein antibody, STIP1 homology and U-box containing protein 1 antibody, STIP1 homology and U-Box containing protein 1 antibody, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog antibody, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase antibody, STIP1 homology and U box-containing protein 1 antibody, carboxyl terminus of HSC70-interacting protein antibody, STUB1 antibody, Stub1 antibody, stub1 antibody, stub1.L antibody, LOC100282870 antibody, CHIP antibody

Background:

Background: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at \\\'Lys-41\\\', \\\'Lys-61\\\' and \\\'Lys-81\\\', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).

Aliases: Antigen NY CO 7 antibody, Antigen NY-CO-7 antibody, C terminus of Hsp70-interacting protein antibody, Carboxy terminus of Hsp70 interacting protein antibody, Carboxy terminus of Hsp70-interacting protein antibody, Carboxy terminus of Hsp70p interacting protein antibody, CHIP antibody, CHIP_HUMAN antibody, CLL associated antigen KW 8 antibody, CLL-associated antigen KW-8 antibody, E3 ubiquitin protein ligase CHIP antibody, E3 ubiquitin-protein ligase CHIP antibody, Heat shock protein A binding protein 2 (c terminal) antibody, HSPABP2 antibody, NY CO 7 antibody, PP1131 antibody, SDCCAG7 antibody, Serologically defined colon cancer antigen 7 antibody, STIP1 homology and U Box containing protein 1 antibody, STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody, STIP1 homology and U box-containing protein 1 antibody, STUB 1 antibody, STUB1 antibody, UBOX 1 antibody, UBOX1 antibody

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation