ARIH2 antibody (AA 43-360)

Catalog No. ABIN7150983

Product Details anti-ARIH2 Antibody

Target: ARIH2 (protein ariadne-2 homolog (ARIH2))

Binding Specificity: AA 43-360

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARIH2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase ARIH2 protein (43-360AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARIH2

Target: ARIH2 (protein ariadne-2 homolog (ARIH2))

Alternative Name: ARIH2 (ARIH2 Products)

Synonyms: ARI2 antibody, TRIAD1 antibody, AI843547 antibody, UIP48 antibody, wu:fa09c12 antibody, zgc:64093 antibody, ariadne RBR E3 ubiquitin protein ligase 2 antibody, ariadne RBR E3 ubiquitin protein ligase 2 L homeolog antibody, ariadne homolog 2 (Drosophila) antibody, ARIH2 antibody, Arih2 antibody, arih2.L antibody, arih2 antibody

Background:

Background: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates \\\'Lys-6\\\', \\\'Lys-48\\\'-and \\\'Lys-63\\\'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).

Aliases: HT005 antibody, all trans retinoic acid inducible RING finger antibody, Ari 2 antibody, Ari-2 antibody, ARI2 antibody, ARI2_HUMAN antibody, Ariadne 2 antibody, Ariadne 2 protein homolog antibody, ariadne homolog 2 (Drosophila) antibody, ariadne homolog 2 antibody, Ariadne RBR E3 ubiquitin protein ligase 2 antibody, ARIH 2 antibody, Arih2 antibody, E3 ubiquitin protein ligase ARIH2 antibody, E3 ubiquitin-protein ligase ARIH2 antibody, protein ariadne 2 homolog antibody, Protein ariadne-2 homolog antibody, Triad 1 antibody, TRIAD1 antibody, Triad1 protein antibody, UIP48 antibody

UniProt: O95376