NSMCE2 antibody (AA 1-247) (HRP)

Catalog No. ABIN7150962

Product Details anti-NSMCE2 Antibody (HRP)

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Binding Specificity: AA 1-247

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NSMCE2 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 SUMO-protein ligase NSE2 protein (1-247AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NSMCE2

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Alternative Name: NSMCE2 (NSMCE2 Products)

Synonyms: 1110014D18Rik antibody, AI661537 antibody, RGD1305156 antibody, C8orf36 antibody, MMS21 antibody, NSE2 antibody, ZMIZ7 antibody, Non-SMC element 2 antibody, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase antibody, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog antibody, Smc5-6 complex non-SMC subunit 2 antibody, Nsmce2 antibody, NSMCE2 antibody, nsmce2.L antibody, nse2 antibody

Background:

Background: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

Aliases: C8orf36 antibody, E3 SUMO-protein ligase NSE2 antibody, hMMS21 antibody, hNSE2 antibody, methyl methanesulfonate sensitivity gene 21 antibody, MMS21 antibody, MMS21 homolog antibody, non-SMC element 2 antibody, Non-SMC element 2 homolog antibody, Non-structural maintenance of chromosomes element 2 homolog antibody, NSE2 antibody, NSE2_HUMAN antibody, Nsmce2 antibody

UniProt: Q96MF7