Mre11 antibody (AA 1-205)

Catalog No. ABIN7150624

Product Details anti-Mre11 Antibody

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Binding Specificity: AA 1-205

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Double-strand break repair protein MRE11A protein (1-205AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Alternative Name: MRE11 (MRE11A Products)

Synonyms: wu:faa63d12 antibody, zgc:64018 antibody, Mre11 antibody, Mre11b antibody, ATLD antibody, HNGS1 antibody, MRE11 antibody, MRE11B antibody, MRE11 homolog A, double strand break repair nuclease antibody, MRE11 homolog, double strand break repair nuclease antibody, MRE11A homolog A, double strand break repair nuclease antibody, mre11a antibody, MRE11 antibody, Mre11a antibody

Background:

Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3\\\'-5\\\' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

Aliases: AT like disease antibody, Ataxia telangiectasia disorder like antibody, ATLD antibody, DNA recombination and repair protein antibody, Double strand break repair protein MRE11A antibody, Double-strand break repair protein MRE11A antibody, endo/exonuclease Mre11 antibody, HNGS1 antibody, meiotic recombination (S. cerevisiae) 11 homolog A antibody, Meiotic recombination 11 homolog 1 antibody, meiotic recombination 11 homolog A (S. cerevisiae) antibody, Meiotic recombination 11 homolog A antibody, M mMRE11A antibody, Mre 11 antibody, MRE 11a antibody, MRE 11b antibody, MRE11 homolog 1 antibody, MRE11 homolog A antibody, MRE11 homolog double strand break repair nuclease antibody, MRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibody, MRE11 meiotic recombination 11 homolog A antibody, MRE11_HUMAN antibody, MRE11A antibody, MRE11b antibody, OTTHUMP00000236830 antibody, OTTHUMP00000236831 antibody, OTTHUMP00000236832 antibody, OTTHUMP00000236833 antibody

UniProt: P49959

Pathways: DNA Damage Repair