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RFX6 antibody (AA 1-260) (Biotin)

RFX6 Reactivity: Human ELISA Host: Rabbit Polyclonal Biotin
Catalog No. ABIN7150386
  • Target See all RFX6 Antibodies
    RFX6 (Regulatory Factor X 6 (RFX6))
    Binding Specificity
    • 4
    • 4
    • 1
    • 1
    • 1
    AA 1-260
    Reactivity
    • 19
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 17
    • 2
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RFX6 antibody is conjugated to Biotin
    Application
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human DNA-binding protein RFX6 protein (1-260AA)
    Isotype
    IgG
    Top Product
    Discover our top product RFX6 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    RFX6 (Regulatory Factor X 6 (RFX6))
    Alternative Name
    RFX6 (RFX6 Products)
    Synonyms
    MTFS antibody, RFXDC1 antibody, dJ955L16.1 antibody, 4930572O07Rik antibody, Rfxdc1 antibody, regulatory factor X6 antibody, regulatory factor X, 6 antibody, RFX6 antibody, Rfx6 antibody
    Background

    Background: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).

    Aliases: RFX6 antibody, RFXDC1 antibody, DNA-binding protein RFX6 antibody, Regulatory factor X 6 antibody, Regulatory factor X domain-containing protein 1 antibody

    UniProt
    Q8HWS3
    Pathways
    Carbohydrate Homeostasis
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