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TOP1MT antibody (AA 270-400) (FITC)

TOP1MT Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7150353
  • Target See all TOP1MT Antibodies
    TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))
    Binding Specificity
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 270-400
    Reactivity
    • 28
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 18
    • 12
    Rabbit
    Clonality
    • 16
    • 14
    Polyclonal
    Conjugate
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TOP1MT antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human DNA topoisomerase I, mitochondrial protein (270-400AA)
    Isotype
    IgG
    Top Product
    Discover our top product TOP1MT Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))
    Alternative Name
    TOP1MT (TOP1MT Products)
    Synonyms
    2900052H09Rik antibody, TOP1 antibody, topoisomerase (DNA) I, mitochondrial antibody, DNA topoisomerase 1, mitochondrial antibody, DNA topoisomerase I mitochondrial antibody, TOP1MT antibody, Top1mt antibody
    Background

    Background: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3\'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5\'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5\'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).

    Aliases: TOP1MT antibody, DNA topoisomerase I antibody, mitochondrial antibody, TOP1mt antibody, EC 5.6.2.1 antibody

    UniProt
    Q969P6
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