TOPBP1 antibody (AA 1253-1522)

Catalog No. ABIN7150350

Product Details anti-TOPBP1 Antibody

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Binding Specificity: AA 1253-1522

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOPBP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human DNA topoisomerase 2-binding protein 1 protein (1253-1522AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TOPBP1

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Alternative Name: TOPBP1 (TOPBP1 Products)

Synonyms: RGD1562949 antibody, TOPBP1 antibody, cut5 antibody, F2P24.3 antibody, F2P24_3 antibody, meiosis defective 1 antibody, TOP2BP1 antibody, 1110031N14Rik antibody, 2810429C13Rik antibody, AI256758 antibody, D430026L04Rik antibody, mKIAA0259 antibody, TopBP1-A antibody, TopBP1-B antibody, Xmus101 antibody, XtopBP antibody, mus101 antibody, top2bp1 antibody, DNA topoisomerase II binding protein 1 antibody, topoisomerase (DNA) II binding protein 1 antibody, dna topoisomerase ii binding protein 1 (IC) antibody, transcription coactivator antibody, DNA topoisomerase II binding protein 1 L homeolog antibody, Topbp1 antibody, topbp1 antibody, TOPBP1 antibody, MEI1 antibody, topbp1.L antibody

Background:

Background: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Aliases: DNA topoisomerase 2 binding protein 1 antibody, DNA topoisomerase 2-binding protein 1 antibody, DNA topoisomerase II binding protein 1 antibody, DNA topoisomerase II binding protein antibody, DNA topoisomerase II-beta-binding protein 1 antibody, DNA topoisomerase II-binding protein 1 antibody, DNA topoisomerase IIbeta binding protein 1 antibody, Hypothetical protein KIAA0259 [Fragment] antibody, KIAA0259 antibody, TOP2BP1 antibody, TOPB1_HUMAN antibody, TOPBP 1 antibody, TopBP1 antibody, Topoisomerase (DNA) II binding protein 1 antibody, Topoisomerase II binding protein 1 antibody

UniProt: Q92547

Pathways: Chromatin Binding