POLI antibody (AA 458-711)
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- Target See all POLI Antibodies
- POLI (Polymerase (DNA Directed) iota (POLI))
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Binding Specificity
- AA 458-711
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POLI antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human DNA polymerase iota protein (458-711AA)
- Isotype
- IgG
- Top Product
- Discover our top product POLI Primary Antibody
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anti-Polymerase (DNA Directed) iota (POLI) (AA 616-715) antibody
POLI Reactivity: Human WB, ELISA Host: Mouse Monoclonal 8G9 unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (N-Term) antibodyPOLI Reactivity: Human, Rat, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (N-Term) antibodyPOLI Reactivity: Human WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 458-740) antibodyPOLI Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 1B9 unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 50-350) antibodyPOLI Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (C-Term) antibodyPOLI Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 51-150) antibodyPOLI Reactivity: Rat ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 143-192) antibodyPOLI Reactivity: Human, Rat, Mouse, Horse, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Monkey, Pig, Bat WB Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (N-Term) antibodyPOLI Reactivity: Human, Rat, Mouse, Horse, Cow, Zebrafish (Danio rerio), Dog, Guinea Pig, Rabbit, Saccharomyces cerevisiae WB Host: Rabbit Polyclonal unconjugated
anti-Polymerase (DNA Directed) iota (POLI) (AA 673-701), (C-Term) antibodyPOLI Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- POLI (Polymerase (DNA Directed) iota (POLI))
- Alternative Name
- POLI (POLI Products)
- Background
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Background: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5\'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Aliases: DNA polymerase iota antibody, Eta 2 antibody, Eta2 antibody, POLI antibody, POLI_HUMAN antibody, Polymerase (DNA directed) iota antibody, RAD 30B antibody, RAD30 homolog B antibody, RAD30, S. cerevisiae, homolog of antibody, RAD30B antibody, RAD3OB antibody
- UniProt
- Q9UNA4
- Pathways
- DNA Damage Repair
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