APOBEC3F antibody (AA 139-287)
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- Target See all APOBEC3F Antibodies
- APOBEC3F (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3F (APOBEC3F))
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Binding Specificity
- AA 139-287
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APOBEC3F antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human DNA dC->dU-editing enzyme APOBEC-3F protein (139-287AA)
- Isotype
- IgG
- Top Product
- Discover our top product APOBEC3F Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- APOBEC3F (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3F (APOBEC3F))
- Alternative Name
- APOBEC3F (APOBEC3F Products)
- Synonyms
- A3F antibody, ARP8 antibody, BK150C2.4.MRNA antibody, KA6 antibody, APOBEC3F antibody, apolipoprotein B mRNA editing enzyme catalytic subunit 3F antibody, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F antibody, APOBEC3F antibody
- Background
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Background: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Aliases: A3F antibody, ABC3F_HUMAN antibody, APOBEC3F antibody, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide like 3F antibody, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F antibody, ARP8 antibody, DNA dC->dU-editing enzyme APOBEC-3F antibody, Induced upon T cell activation antibody, KA6 antibody
- UniProt
- Q8IUX4
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