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DDB2 antibody (AA 1-185) (FITC)

DDB2 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7150130
  • Target See all DDB2 Antibodies
    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
    Binding Specificity
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-185
    Reactivity
    • 37
    • 17
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 36
    • 3
    Rabbit
    Clonality
    • 27
    • 12
    Polyclonal
    Conjugate
    • 22
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This DDB2 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human DNA damage-binding protein 2 protein (1-185AA)
    Isotype
    IgG
    Top Product
    Discover our top product DDB2 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
    Alternative Name
    DDB2 (DDB2 Products)
    Synonyms
    2610043A19Rik antibody, si:dkey-45f10.3 antibody, DDBB antibody, UV-DDB2 antibody, damage specific DNA binding protein 2 antibody, damage-specific DNA binding protein 2 antibody, DDB2 antibody, ddb2 antibody, Ddb2 antibody
    Background

    Background: Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

    Aliases: damage-specific DNA binding protein 2 antibody, Damage-specific DNA-binding protein 2 antibody, DDB p48 subunit antibody, Ddb2 antibody, DDB2_HUMAN antibody, DDBb antibody, DNA damage-binding protein 2 antibody, UV-damaged DNA-binding protein 2 antibody, UV-DDB 2 antibody, Xeroderma pigmentosum group E protei antibody

    UniProt
    Q92466
    Pathways
    DNA Damage Repair
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