ZRANB3 antibody (AA 370-624) (HRP)

Catalog No. ABIN7150123

Product Details anti-ZRANB3 Antibody (HRP)

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Binding Specificity: AA 370-624

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZRANB3 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ZRANB3

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Alternative Name: ZRANB3 (ZRANB3 Products)

Synonyms: 4933425L19Rik antibody, AH2 antibody, AI316834 antibody, C730006D09 antibody, zinc finger RANBP2-type containing 3 antibody, zinc finger, RAN-binding domain containing 3 antibody, ZRANB3 antibody, Zranb3 antibody

Background:

Background: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3\\\'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Aliases: 4933425L19Rik antibody, AH2 antibody, Annealing helicase 2 antibody, DNA annealing helicase and endonuclease ZRANB3 antibody, MGC105033 antibody, MGC75012 antibody, OTTHUMP00000197449 antibody, Zinc finger Ran-binding domain-containing protein 3 antibody, Zinc finger, RAN- binding domain containing 3 antibody, ZRAB3_HUMAN antibody, Zranb3 antibody

UniProt: Q5FWF4