DLG5 antibody (AA 1580-1704) (Biotin)

Catalog No. ABIN7150081

Product Details anti-DLG5 Antibody (Biotin)

Target: DLG5 (Discs, Large Homolog 5 (DLG5))

Binding Specificity: AA 1580-1704

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLG5 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Disks large homolog 5 protein (1580-1704AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DLG5

Target: DLG5 (Discs, Large Homolog 5 (DLG5))

Alternative Name: DLG5 (DLG5 Products)

Synonyms: DLG5 antibody, dlg5 antibody, wu:fc28f03 antibody, LP-DLG antibody, P-DLG5 antibody, PDLG antibody, 4933429D20Rik antibody, T25557 antibody, mKIAA0583 antibody, discs large MAGUK scaffold protein 5 antibody, discs, large homolog 5 (Drosophila) antibody, discs, large homolog 5a (Drosophila) antibody, DLG5 antibody, dlg5a antibody, Dlg5 antibody

Background:

Background: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons, regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Aliases: Discs large homolog 5 (Drosophila) antibody, Discs large homolog 5 antibody, Discs large protein LP DLG antibody, Discs large protein P dlg antibody, Discs large protein P-dlg antibody, Disks large homolog 5 antibody, DLG 5 antibody, DLG5 antibody, DLG5_HUMAN antibody, KIAA0583 antibody, Large type of P DLG antibody, LP DLG antibody, P DLG5 antibody, PDLG antibody, Placenta and prostate DLG antibody

UniProt: Q8TDM6