DIS3L2 antibody (AA 201-400) (Biotin)

Catalog No. ABIN7150018

Product Details anti-DIS3L2 Antibody (Biotin)

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Binding Specificity: AA 201-400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIS3L2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human DIS3-like exonuclease 2 protein (201-400AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Alternative Name: DIS3L2 (DIS3L2 Products)

Synonyms: RGD1560168 antibody, DIS3L2 antibody, DKFZp469O0522 antibody, FAM6A antibody, PRLMNS antibody, hDIS3L2 antibody, 4930429A22Rik antibody, 8030493P09Rik antibody, DIS3-like 3'-5' exoribonuclease 2 antibody, DIS3 like 3'-5' exoribonuclease 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, DIS3L2 antibody, LOC100344728 antibody

Background:

Background: 3\'-5\'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3\' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3\'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

Aliases: DI3L2_HUMAN antibody, DIS3 L2 antibody, DIS3 mitotic control homolog (S. cerevisiae) like 2 antibody, DIS3 mitotic control homolog like 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, FLJ36974 antibody, MGC42174 antibody

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance