DKK4 antibody (AA 19-224)

Catalog No. ABIN7149890

Product Details anti-DKK4 Antibody

Target: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Binding Specificity: AA 19-224

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Dickkopf-related protein 4 protein (19-224AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DKK4

Target: DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))

Alternative Name: DKK4 (DKK4 Products)

Synonyms: DKK-4 antibody, Dkk-4 antibody, RGD1563172 antibody, dickkopf WNT signaling pathway inhibitor 4 antibody, DKK4 antibody, Dkk4 antibody

Background:

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Aliases: Dickkopf 4 antibody, Dickkopf gene 4 antibody, Dickkopf homolog 4 (Xenopus laevis) antibody, Dickkopf homolog 4 antibody, Dickkopf related protein 4 antibody, Dickkopf-4 antibody, Dickkopf-related protein 4 short form antibody, Dickkopf4 antibody, DKK 4 antibody, Dkk-4 antibody, DKK4 antibody, DKK4_HUMAN antibody, hDkk 4 antibody, hDkk-4 antibody, hDkk4 antibody, MGC129562 antibody, MGC129563 antibody

UniProt: Q9UBT3

Pathways: WNT Signaling