DKK2 antibody (AA 34-259)

Catalog No. ABIN7149882

Product Details anti-DKK2 Antibody

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Binding Specificity: AA 34-259

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dickkopf-related protein 2 protein (34-259AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DKK2

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Alternative Name: DKK2 (DKK2 Products)

Synonyms: DKK-2 antibody, Dkk4 antibody, zgc:171574 antibody, dickkopf WNT signaling pathway inhibitor 2 antibody, DKK2 antibody, Dkk2 antibody, dkk2 antibody

Background:

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Aliases: Dickkopf 2 antibody, Dickkopf gene 2 antibody, Dickkopf homolog 2 antibody, Dickkopf related protein 2 antibody, Dickkopf WNT signaling pathway inhibitor 2 antibody, Dickkopf-2 antibody, Dickkopf-related protein 2 antibody, Dickkopf2 antibody, DKK 2 antibody, Dkk-2 antibody, Dkk2 antibody, DKK2_HUMAN antibody, hDkk 2 antibody, hDkk-2 antibody, hDkk2 antibody

UniProt: Q9UBU2

Pathways: WNT Signaling