DKK1 antibody (AA 33-266)

Catalog No. ABIN7149878

Product Details anti-DKK1 Antibody

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Binding Specificity: AA 33-266

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dickkopf-related protein 1 protein (33-266AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DKK1

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Alternative Name: DKK1 (DKK1 Products)

Synonyms: DKK-1 antibody, SK antibody, AI414495 antibody, SGY antibody, SGY-1 antibody, SGY1 antibody, Soggy antibody, mSgy antibody, dkk1 antibody, dkk antibody, dkk-1 antibody, xdkk1 antibody, Xdkk-1 antibody, Dickkopf1 antibody, dickkopf-1 antibody, mdkk-1 antibody, dkk1-A antibody, dickkopf WNT signaling pathway inhibitor 1 antibody, dickkopf like acrosomal protein 1 antibody, dickkopf-related protein 1 antibody, dickkopf-like 1 antibody, dickkopf WNT signaling pathway inhibitor 1b antibody, dickkopf protein antibody, dickkopf WNT signaling pathway inhibitor 1 S homeolog antibody, DKK1 antibody, Dkk1 antibody, DKKL1 antibody, LOC100228789 antibody, Dkkl1 antibody, dkk1b antibody, dkk1 antibody, dickkopf antibody, dkk1.S antibody

Background:

Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Aliases: Dickkopf 1 antibody, Dickkopf 1 homolog antibody, Dickkopf 1 like antibody, Dickkopf homolog 1 antibody, Dickkopf like protein 1 antibody, Dickkopf related protein 1 antibody, Dickkopf WNT signaling pathway inhibitor 1 antibody, Dickkopf-1 antibody, Dickkopf-related protein 1 antibody, DKK 1 antibody, Dkk-1 antibody, Dkk1 antibody, DKK1_HUMAN antibody, hDkk 1 antibody, hDkk-1 antibody, SK antibody

UniProt: O94907

Pathways: WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation