DHRS2 antibody (AA 1-300)

Catalog No. ABIN7149618

Product Details anti-DHRS2 Antibody

Target: DHRS2 (Dehydrogenase/reductase (SDR Family) Member 2 (DHRS2))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHRS2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Dehydrogenase/reductase SDR family member 2, mitochondrial protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DHRS2

Target: DHRS2 (Dehydrogenase/reductase (SDR Family) Member 2 (DHRS2))

Alternative Name: DHRS2 (DHRS2 Products)

Synonyms: DHRS2 antibody, HEP27 antibody, SDR25C1 antibody, 5430405K24Rik antibody, Hep27 antibody, dehydrogenase/reductase 4 antibody, dehydrogenase/reductase 2 antibody, dehydrogenase/reductase member 2 antibody, DHRS4 antibody, DHRS2 antibody, Dhrs2 antibody

Background:

Background: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Aliases: DHRS2 antibody, SDR25C1 antibody, Dehydrogenase/reductase SDR family member 2 antibody, mitochondrial antibody, EC 1.1.1.- antibody, Dicarbonyl reductase HEP27 antibody, Protein D antibody, Short chain dehydrogenase/reductase family 25C member 1 antibody

UniProt: Q13268

Pathways: C21-Steroid Hormone Metabolic Process