DOCK3 antibody (AA 1630-1934)

Catalog No. ABIN7149587

Product Details anti-DOCK3 Antibody

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Binding Specificity: AA 1630-1934

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dedicator of cytokinesis protein 3 protein (1630-1934AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DOCK3

Target: DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))

Alternative Name: DOCK3 (DOCK3 Products)

Synonyms: MOCA antibody, PBP antibody, mKIAA0299 antibody, dedicator of cytokinesis 3 antibody, similar to dedicator of cytokinesis 3 antibody, dedicator of cytokinesis protein 3 antibody, dedicator of cyto-kinesis 3 antibody, DOCK3 antibody, LOC561387 antibody, dock3 antibody, LOC100474164 antibody, Dock3 antibody

Background:

Background: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).

Aliases: DOCK3 antibody, KIAA0299 antibody, MOCADedicator of cytokinesis protein 3 antibody, Modifier of cell adhesion antibody, Presenilin-binding protein antibody, PBP antibody

UniProt: Q8IZD9