BMX antibody (AA 65-280)

Catalog No. ABIN7149358

Product Details anti-BMX Antibody

Target: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Binding Specificity: AA 65-280

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMX antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Cytoplasmic tyrosine-protein kinase BMX protein (65-280AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BMX

Target: BMX (BMX Non-Receptor Tyrosine Kinase (BMX))

Alternative Name: BMX (BMX Products)

Synonyms: BMX antibody, ETK antibody, PSCTK2 antibody, PSCTK3 antibody, Etk antibody, Etk/Bmx antibody, Tyro8 antibody, RGD1565643 antibody, BMX non-receptor tyrosine kinase antibody, BMX antibody, bmx antibody, Bmx antibody

Background:

Background: Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells, as well as in signal transduction in endocardial and arterial endothelial cells.

Aliases: Bmx antibody, BMX non receptor tyrosine kinase antibody, BMX_HUMAN antibody, BONE MARROW KINASE, X-LINKED antibody, Bone marrow tyrosine kinase gene in chromosome X protein antibody, Cytoplasmic tyrosine protein kinase BMX antibody, Cytoplasmic tyrosine-protein kinase BMX antibody, Epithelial and endothelial tyrosine kinase antibody, ETK antibody, NKT38 antibody, NTK 38 antibody, NTK38 antibody, Protein tyrosine kinase BMX antibody, PSCTK 2 antibody, PSCTK 3 antibody, PSCTK2 antibody, PSCTK3 antibody

UniProt: P51813