CPEB4 antibody (AA 244-515) (HRP)
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- Target See all CPEB4 products
- CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4))
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Binding Specificity
- AA 244-515
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CPEB4 antibody is conjugated to HRP
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)
- Isotype
- IgG
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4))
- Alternative Name
- CPEB4 (CPEB4 Products)
- Synonyms
- DKFZp468L052 antibody, 4930447D24Rik antibody, AI851572 antibody, mKIAA1673 antibody, Cpeb3 antibody, zgc:66166 antibody, cytoplasmic polyadenylation element binding protein 4 antibody, cytoplasmic polyadenylation element binding protein 4 S homeolog antibody, cytoplasmic polyadenylation element binding protein 4a antibody, CPEB4 antibody, cpeb4 antibody, cpeb4.S antibody, Cpeb4 antibody, cpeb4a antibody
- Background
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Background: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5\\\'-UUUUUAU-3\\\') within the mRNA 3\\\'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).
Aliases: CPE binding protein 4 antibody, CPE-binding protein 4 antibody, CPE-BP4 antibody, cpeb4 antibody, CPEB4_HUMAN antibody, Cytoplasmic polyadenylation element binding protein 4 antibody, Cytoplasmic polyadenylation element-binding protein 4 antibody, hCPEB-4 antibody, KIAA1673 antibody
- UniProt
- Q17RY0
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