CPEB4 antibody (AA 244-515) (Biotin)

Catalog No. ABIN7149349

Product Details anti-CPEB4 Antibody (Biotin)

Target: CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4))

Binding Specificity: AA 244-515

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPEB4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CPEB4

Target: CPEB4 (Cytoplasmic Polyadenylation Element Binding Protein 4 (CPEB4))

Alternative Name: CPEB4 (CPEB4 Products)

Synonyms: DKFZp468L052 antibody, 4930447D24Rik antibody, AI851572 antibody, mKIAA1673 antibody, Cpeb3 antibody, zgc:66166 antibody, cytoplasmic polyadenylation element binding protein 4 antibody, cytoplasmic polyadenylation element binding protein 4 S homeolog antibody, cytoplasmic polyadenylation element binding protein 4a antibody, CPEB4 antibody, cpeb4 antibody, cpeb4.S antibody, Cpeb4 antibody, cpeb4a antibody

Background:

Background: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5\\\'-UUUUUAU-3\\\') within the mRNA 3\\\'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).

Aliases: CPE binding protein 4 antibody, CPE-binding protein 4 antibody, CPE-BP4 antibody, cpeb4 antibody, CPEB4_HUMAN antibody, Cytoplasmic polyadenylation element binding protein 4 antibody, Cytoplasmic polyadenylation element-binding protein 4 antibody, hCPEB-4 antibody, KIAA1673 antibody

UniProt: Q17RY0