CPEB3 antibody (AA 414-525) (HRP)

Catalog No. ABIN7149347

Product Details anti-CPEB3 Antibody (HRP)

Target: CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3 (CPEB3))

Binding Specificity: AA 414-525

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPEB3 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CPEB3

Target: CPEB3 (Cytoplasmic Polyadenylation Element Binding Protein 3 (CPEB3))

Alternative Name: CPEB3 (CPEB3 Products)

Synonyms: si:ch211-129m12.2 antibody, 4831444O18Rik antibody, mKIAA0940 antibody, RGD1564670 antibody, cytoplasmic polyadenylation element binding protein 3 antibody, cpeb3 antibody, CPEB3 antibody, LOAG_07772 antibody, Cpeb3 antibody

Background:

Background: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3\'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3\'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3\'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195).

Aliases: CPE-binding protein 3 antibody, CPE-BP3 antibody, CPEB 3 antibody, CPEB3 antibody, CPEB3_HUMAN antibody, Cytoplasmic polyadenylation element binding protein 3 antibody, Cytoplasmic polyadenylation element-binding protein 3 antibody, hCPEB-3 antibody, KIAA0940 antibody

UniProt: Q8NE35