ATG4C antibody (AA 419-448)

Catalog No. ABIN7149026

Product Details anti-ATG4C Antibody

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Binding Specificity: AA 419-448

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG4C antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cysteine protease ATG4C protein (419-448AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ATG4C

Target: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Alternative Name: ATG4C (ATG4C Products)

Synonyms: apg4c antibody, atg4cl antibody, zgc:86888 antibody, wu:fc56g07 antibody, APG4-C antibody, APG4C antibody, AUTL1 antibody, AUTL3 antibody, Apg4-C antibody, Apg4c antibody, Atg4cl antibody, Autl1 antibody, autophagy related 4C cysteine peptidase antibody, autophagy related 4C, cysteine peptidase antibody, cysteine protease ATG4C antibody, ATG4C antibody, atg4c antibody, Tsp_15996 antibody, Atg4c antibody

Background:

Background: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Aliases: APG4 autophagy 4 homolog C (S. cerevisiae) antibody, APG4 autophagy 4 homolog C antibody, APG4 C antibody, APG4-C antibody, APG4C antibody, ATG 4C antibody, ATG4 autophagy related 4 homolog C (S. cerevisiae) antibody, ATG4 autophagy related 4 homolog C antibody, Atg4c antibody, ATG4C_HUMAN antibody, AUT (S. cerevisiae) like 1, cysteine endopeptidase antibody, AUT like 1, cysteine endopeptidase (S. cerevisiae) antibody, AUT like 1, cysteine endopeptidase antibody, AUT like 3 cysteine endopeptidase antibody, AUT-like 3 cysteine endopeptidase antibody, AUTL1 antibody, AUTL3 antibody, Autophagin 3 antibody, Autophagin-3 antibody, Autophagy related 4C cysteine peptidase antibody, Autophagy related cysteine endopeptidase 3 antibody, Autophagy related protein 4 homolog C antibody, Autophagy-related cysteine endopeptidase 3 antibody, Autophagy-related protein 4 homolog C antibody, Cysteine protease ATG4C antibody, EC 3.4.22 antibody, FLJ14867 antibody, OTTHUMP00000010715 antibody

UniProt: Q96DT6

Pathways: Autophagy